new presentation of corneal epithelial graft rejection

Scanning electron microscopy of corneal graft rejection: epithelial rejection, endothelial rejection, and formation of posterior graft membranes.

Penetrating corneal homografts were performed in rabbits for the purpose of making, surface studies ivith the scanning electron microscope at various stages of rejection. The rejection of graft epithelium was characterized by a disruption and breakdown of its normal structure in an area 60 to 80 nm. in width. Desquamated cells, pits, and craters were observed in the area of rejection which move...

New drugs in prevention of experimental corneal graft rejection

Immune factors in corneal graft rejection.

This panorama of the immune factors in corneal graft rejection covers a spectrum of mechanisms which play a role in the opacification of corneal grafts. Great emphasis has been accorded to the role of transplantation immunity. The clinical and experimental evidence implicating transplantation immunity in the rejection of corneal grafts has been critically reviewed. In addition, evidence is pres...

Corneal Graft Rejection; Prevalence and Risk Factors

Background: Rejection is the most common cause of late corneal graft failure. The purpose of this study is determining the prevalence, and defining the role of those factors which may affect the risk for rejection. Methods: The study was conducted on all patients who had penetrating keratoplasty without immunosuppressive therapy with at least 1 year follow up. Demographic status, cause of graft...

Corneal epithelial rejection in the rat.

PURPOSE To investigate clinical and histologic changes in the epithelium during corneal graft rejection in the rat. METHODS LEW (RT1(l)) or PVG (RT1(c)) strain corneas were transplanted to PVG strain recipients and examined by slit lamp for clinical signs of rejection. Recipients were killed, and corneal epithelial sheets were removed and examined by adenosine diphosphatase (ADPase) staining ...

Prognostic factors for corneal graft recovery after severe corneal graft rejection following penetrating keratoplasty

BACKGROUND To investigate the outcome and prognostic factors for corneal graft recovery after severe corneal graft rejection following penetrating keratoplasty (PKP) treated with topical and systemic steroids. METHODS Fifty-eight eyes in 58 patients with severe corneal graft rejection following PKP were treated with topical and systemic steroids. Factors affecting the reversibility and mainte...